The Esophageal Cascade: Reflux, Inflammation, Metaplasia, Dysplasia, and Neoplasia

The case presented here illustrates the possible complications of gastroesophageal reflux disease (GERD). In its simple form, GERD poses no expectation of extra mortality. However, certain histopathologic complications of GERD predispose to the development of esophageal adenocarcinoma. The clinical course, diagnosis, treatment, prognosis, and preventive surveillance of GERD and Barrett metaplasia are discussed. Address: American United Life Insurance Company, PO Box 109-B, One American Square, Indianapolis, IN 46206-9101.